![]() ![]() The figure on page 20 of this document helps to illustrate the results from the evidence, for both the primary series as well as for a booster dose.Īnother evidence review, published by McMaster University on June 22, 2022, also examined the effectiveness of COVID-19 vaccines against the Omicron variant. However, boosting with a third dose increased the VE against infection with Omicron (to about 60%) and against severe outcomes (to 90%). VE against infection by Omicron was lower than for previous variants and waned over time with most protection against infection lost by 4-6 months post second dose. For considerations on these doses, see Ī systematic review of the evidence published between December 2021 and April 2022 in The Lancet Infectious Diseases found that the VE of a primary series (for most people, this is two doses) against severe outcomes remained high and stable over time at over 80%. ![]() Booster doses are most important for those at high risk of severe outcomes. ![]() Immunity against infection wanes over time, but can be boosted with an another dose of an mRNA vaccine.
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